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KMID : 0369820160460070645
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Jorunal of Korean Pharmaceutical Sciences
2016 Volume.46 No. 7 p.645 ~ p.653
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Sodium alginate?arabinoxylan composite microbeads: preparation and characterization
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Ahuja Munish
Bhatia Meenakshi
Saini Komal
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Abstract
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The objective of present study was to prepare composite microbeads of psyllium arabinoxylan and sodium alginate by ionotropic gelation method using calcium chloride as a cross linker and was further evaluated for release study. The effect of concentration of sodium alginate/arabinoxylan and concentration of calcium chloride on the entrapment efficiency and on % release were studied employing 2-factor, 3-level central composite experimental design. The results of the study revealed that interaction effect of the concentration of sodium alginate/arabinoxylan and calcium chloride influenced the entrapment efficiency and release of diclofenac sodium significantly. The optimal calculated parameters were found to be concentration of sodium alginate/arabinoxylan-5 and concentration of calcium chloride-0.75 M, that provided microbeads with entrapment efficiency-64.4 % and release of 28.5 % of the drug over 8 h period of study. Further, arabinoxylan?sodium alginate mucoadhesive microbeads were found to sustain the release of diclofenac sodium over a period of 8 h following zero order kinetics with the mechanism of release being diffusion.
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KEYWORD
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Arabinoxylan, Sodium alginate, Microbeads, Mucoadhesion
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